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  • Title: In-vitro and in-vivo antibacterial activity of imipenem against clinical isolates of bacteria.
    Author: Mitsuhashi S.
    Journal: J Antimicrob Chemother; 1983 Dec; 12 Suppl D():53-64. PubMed ID: 6607914.
    Abstract:
    Imipenem, a derivative of thienamycin, a carbapenem antibiotic, has a broad spectrum of activity against aerobic (Gram-positive and Gram-negative) and anaerobic bacteria. It is quite stable to all tested beta-lactamases produced by various species of bacteria isolated from clinical specimens, whether plasmid or chromosomally mediated. One exception is its hydrolysis by the beta-lactamase produced by Pseudomonas maltophilia which is thus usually resistant to imipenem. Imipenem was found to be hydrolysed by renal dehydropeptidase-I residing on the luminal surface of the renal tubular epithelium. A dehydropeptidase-I inhibitor, cilastatin (MK-0791) was developed with specific inhibitory activity toward the renal dehydropeptidase-I and showed detectable effects in humans.
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