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  • Title: Lymphocytes T and pharmacokinetics after a single oral dose of levamisole in healthy and cancer subjects.
    Author: Luyckx M, Cazin M, Brunet C, Cazin JC, Devulder B, Gosselin P, Adenis L, Cappelaere P, Granier AM, Demaille A.
    Journal: Methods Find Exp Clin Pharmacol; 1983 Sep; 5(7):467-9. PubMed ID: 6608036.
    Abstract:
    Levamisole, an anthelmintic drug with immunopotentiating activity, is shown to have variable effects on cell-mediated immunity. We have studied the effect of a single oral dose (2.5 mg/kg or 5 mg/kg) on early and spontaneous E rosettes percentages in healthy and cancer patients. Pharmacokinetic study of this compound was conducted in parallel. The results indicated that single administration of levamisole (2.5 mg/kg) in healthy men can promote an increase of early E rosettes with mean peak plasma level of 0.8 micrograms. ml-1. On the other hand, there was no change in the proportion of early E rosettes in cancer patients and in the proportion of spontaneous E rosettes in healthy and cancer subjects.
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