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  • Title: Acute oligoarthritis associated with Clostridium difficile pseudomembranous colitis.
    Author: Lofgren RP, Tadlock LM, Soltis RD.
    Journal: Arch Intern Med; 1984 Mar; 144(3):617-9. PubMed ID: 6608328.
    Abstract:
    The abrupt onset of a sterile inflammatory oligoarthritis developed in a patient with active Clostridium difficile pseudomembranous colitis. The arthritis affected a hip and a knee. Leukocyte counts of synovial fluid obtained from the patient's left hip and knee were elevated. He was haplotyped as HLA-B27 antigen-positive. The colitis and arthritis promptly abated after treatment with oral vancomycin hydrochloride. Three other cases of arthritis associated with antibiotic-induced colitis were reviewed. It seems as if treatment of the colitis leads to resolution of the arthritis.
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