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  • Title: [Donor immunization with an inactivated concentrated purified vaccine against tick-borne encephalitis to obtain immune blood preparations].
    Author: El'bert LB, Pervikov IuV, Grachev VP, Rusanov VM, Krokhina MA.
    Journal: Vopr Virusol; 1984; 29(1):56-9. PubMed ID: 6608828.
    Abstract:
    Vaccination of seronegative and seropositive donors with a concentrated purified vaccine (CV) against tick-borne encephalitis induced antibody synthesis in a concentration sufficient for preparation of donor immunoglobulin with antibody titres of 1:320 to 1:1280 by HI test. The resulting preparation showed a high antiviral activity both in vivo and in vitro against antigenically different strains of tick-borne encephalitis virus. The immune plasma derived from CV-immunized donors had a therapeutic effect in patients with tick-borne encephalitis. The optimal schedules for immunization of donors are discussed.
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