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  • Title: Phenol-soluble nonhistone chromatin proteins in chronic lymphocytic leukemia.
    Author: Jones CA, Hesse L, Muzik H, Jerry LM.
    Journal: Cancer Res; 1984 May; 44(5):2068-77. PubMed ID: 6608990.
    Abstract:
    The altered gene expression seen in cancer could relate to differences in nonhistone chromatin proteins between normal and malignant tumor cells. Phenol-soluble nonhistone chromatin proteins were isolated from human normal and leukemic (chronic lymphocytic leukemia) B-cells, as well as long-term cultured human B-lymphocyte cell lines. High-resolution two-dimensional electrophoretic maps identified a group of three nuclear proteins with a molecular weight of 45,000 to 50,000 and an isoelectric range of 4.5 to 4.7, which were associated only with the human leukemic B-cells. Leukemic B-cells and cultured B-cell lines also expressed a variant form of nuclear actin and tubulin.
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