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  • Title: Bacterial modulation of the cellular immune response in mice. II. Stimulation by endotoxin of the reduced cellular immune response to LCM virus infection in aged mice.
    Author: Bános Z, Anderlik P, Szeri I, Wessely M, Bertók L.
    Journal: Acta Microbiol Hung; 1983; 30(3-4):233-7. PubMed ID: 6609515.
    Abstract:
    Aging mice treated with radio-detoxified endotoxin and subsequently inoculated intracerebrally with lymphocytic choriomeningitis (LCM) virus died earlier and in a higher rate than the virus infected and otherwise untreated controls. Thus, in mice with insufficient T lymphocyte function due to aging, the radio-detoxified endotoxin pretreatment contributed to the outcome of LCM virus infection in the form of lethal meningitis. That indicates a stimulatory effect on the reduced cellular immunological reaction to the virus infection.
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