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  • Title: The effect of beta-lactamase stability, penetration, and target affinity on the activity of cefazolin, cefamandole, cefoxitin, and cefuroxime.
    Author: Harper PB.
    Journal: Clin Ther; 1984; 6(3):310-24. PubMed ID: 6609771.
    Abstract:
    Four beta-lactam antibiotics, cefazolin, cefamandole, cefoxitin, and cefuroxime, were tested for their ability to penetrate the bacterial cell wall, to inhibit target proteins, and to resist degradation by beta-lactamase enzymes. Cefuroxime was the only tested antibiotic that performed well in all three categories.
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