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  • Title: [Heterocyclic compounds with potential anti-inflammatory activity containing a 4-aminophenylalkanoic acid residue. V. Derivatives of 2,4-dihydro-3H-pyrazole-3-one].
    Author: Picciòla G, Zavaglio G, Carenini G, Gentili P, Tempra-Gabbiati G.
    Journal: Farmaco Sci; 1984 Apr; 39(4):371-8. PubMed ID: 6609838.
    Abstract:
    The synthesis and pharmacological study of some derivatives of 2,4-dihydro-3H-pyrazol-3-one of general formula (I) are described. The compound in which R = C6H5 and R' = CH3 [2-(4- carboxymethylphenyl )-4-phenyl-5-methyl-2,4- dihydropyrazol -3-one] (MG 18949) proved to have antipyretic activity equal to that of ibuprofen and aminopyrine.
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