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  • Title: An immunogenetic study of older age onset rheumatoid arthritis.
    Author: Terkeltaub R, Décary F, Esdaile J.
    Journal: J Rheumatol; 1984 Apr; 11(2):147-9. PubMed ID: 6610048.
    Abstract:
    Thirty-two patients with older age onset rheumatoid arthritis (ORA), defined as disease onset after age 60, were selected for HLA typing. The majority (69%) were rheumatoid factor (RF) seronegative. An increase in HLA-DR4, though not statistically significant, was seen in ORA (38% vs 17% normals). This antigen was strongly associated with RF seropositivity (70%, p less than 0.01) and rheumatoid nodules (75%, p less than 0.01) in ORA. We conclude that the immunogenetics of ORA are similar to that described for adult RA in general.
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