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  • Title: Resistance to trimethoprim-sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia. Implication of folinic acid.
    Author: Nunn PP, Allistone JC.
    Journal: Chest; 1984 Jul; 86(1):149-50. PubMed ID: 6610537.
    Abstract:
    Pneumocystis carinii pneumonia is a well-known complication of immunosuppression in renal transplant recipients. Treatment is generally with trimethoprim-sulfamethoxazole (TMP-SMZ). A case of Pneumocystis pneumonia failed to respond to TMP-SMZ until concomitant administration of folinic acid was stopped. Physicians should be alerted to the possibility that folinic acid may impair the efficacy of TMP-SMZ in Pneumocystis carinii infection.
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