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  • Title: Research on heterocyclic compounds. XVII. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acids.
    Author: Abignente E, Arena F, Luraschi E, Saturnino C, Marmo E, De Rosis A, Filippelli A.
    Journal: Farmaco Sci; 1984 May; 39(5):379-88. PubMed ID: 6610566.
    Abstract:
    A group of ethyl 2-methylimidazo[1,2-a]pyrimidine-3-carboxylates were prepared by reaction of ethyl 2-chloroacetoacetate with some 2-aminopyrimidines. These ethyl esters were then converted into the corresponding carboxylic acids via alkaline hydrolysis. The acids so obtained were evaluated for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.
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