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  • Title: HLA-DR positive T lymphocytes in blood and synovial fluid in rheumatoid arthritis.
    Author: Kluin-Nelemans HC, van der Linden JA, Gmelig Meyling FH, Schuurman HJ.
    Journal: J Rheumatol; 1984 Jun; 11(3):272-6. PubMed ID: 6610750.
    Abstract:
    HLA-DR expression was found on 6.7 +/- 0.7% of blood T lymphocytes from 34 patients with rheumatoid arthritis (RA) and 2.6 +/- 0.3% of T cells from normals. In synovial fluid (SF) of RA patients high percentages were found (56 +/- 3%, n = 18); the SF T lymphocytes showed an acid alpha-naphthyl acetate esterase pattern and cell morphology compatible with activated T lymphocytes. The helper function for pokeweed mitogen induced B cell differentiation was higher in blood T lymphocytes from RA patients than from normal controls; in SF T lymphocytes helper function could not be established. These differences between blood and SF T lymphocytes may represent differences in recirculating and homing properties of T cells in these compartments.
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