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  • Title: [Dynamics of the formation of anti-idiotypic antibodies in the course of the immune response].
    Author: Kositskaia LS, Sofronov BN.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1984 Apr; (4):83-6. PubMed ID: 6611003.
    Abstract:
    The work demonstrates that after the injection of a heterogenous antigen into rabbits the appearance of antibodies is followed by the "spontaneous" formation of anti-idiotypic antibodies. These anti-antibodies, detected by means of several serological reactions, are specific and have an idiotypic character. Circulating antibody--anti-idiotypic antibody complexes have been detected in the blood of the animals. The injection of autologous anti-idiotypic antibodies into the immunized animals ensures the stimulation of the formation of antibodies and anti-idiotypic antibodies. Immunological memory with respect to anti-idiotypic antibodies develops in the body of the immunized animals.
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