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  • Title: Leukotriene D4 reduces coronary blood flow in the anesthetized dog.
    Author: Panzenbeck MJ, Kaley G.
    Journal: Prostaglandins; 1983 May; 25(5):661-70. PubMed ID: 6611962.
    Abstract:
    We studied the effects of intracoronary administration of leukotriene (LT)D4 on coronary blood flow and myocardial function in chloralose anesthetized dogs. For comparison, the effects of injections of U-46619 were examined in the same dogs. Both LTD4 and U-46619 decreased coronary blood flow, left ventricular dP/dt and cardiac output. LTD4 was ten times more potent than U-46619 in decreasing coronary blood flow. The effects of neither drug were different after indomethacin administration.
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