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  • Title: [Evaluation of the percentage of increased spongy bone in experimental osteoporosis treated with synthetic anabolic agents].
    Author: Carrozzo M, Pallante R, Lo Sasso F, D'Amore M.
    Journal: Rev Rhum Mal Osteoartic; 1983 Jun; 50(7):501-5. PubMed ID: 6612200.
    Abstract:
    In this paper, the authors discuss the variations in the quantity of spongy bone in rats of the same sex, same age and same weight subjected to a normocalcic diet, a hypocalcic diet or a hypocalcic diet plus synthetic anabolic agent. In the rats subjected to a hypocalcic diet, there is a statistically significant reduction in the quantity of spongy bone, in comparison to that of the other two groups. In other words, the hypocalcic diet led to a rarefying osteopathy, which was partially prevented by the use of synthetic anabolic agents. the authors also observed that the rarefying osteopathy was more intense in the distal epiphysis of the femur than in the neck of the femur. If this feature is confirmed in man, it would constitute a precious aid to the early detection of osteoporosis.
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