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  • Title: Turnover, membrane insertion, and degradation of sodium channels in rabbit urinary bladder.
    Author: Loo DD, Lewis SA, Ifshin MS, Diamond JM.
    Journal: Science; 1983 Sep 23; 221(4617):1288-90. PubMed ID: 6612343.
    Abstract:
    Noise analysis of rabbit bladder revealed two components: Lorentzian noise, arising from interaction of amiloride with the Na+ channel, and flicker noise (l/f, where f is frequency), as in other biological membranes. Hydrostatic pressure, which causes exchange between intracellular vesicular membrane and apical membrane, increases the number but not the single-channel current of the amiloride-sensitive channels. Flicker noise arises from degraded channels that have lost amiloride sensitivity and Na+ to K+ selectivity. The degraded channels were selectively removed by washing the mucosal surface. These results imply channel turnover by intracellular synthesis, transfer from vesicular to apical membrane, degradation, and elimination.
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