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  • Title: [Immunological patterns in acute viral hepatitis B].
    Author: Ketiladze ES, Bugaeva NP, Vorozhbieva TE, Savitskiĭ GI.
    Journal: Vopr Virusol; 1983; (3):302-6. PubMed ID: 6613086.
    Abstract:
    The results of studies on hepatitis B markers (HBsAg, anti-HBs, anti-HBc) by highly sensitive methods in 560 patients aged from 15 to 77 years are presented. Three immunologic groups of HB patients were detected. The first group is most numerous (77%), HBsAg is found in the blood of patients in high concentrations by the gel precipitation test. The second group (19%) has a low concentration of HBsAg detectable only by the RIA. The third, smallest (4%), group showed antibodies to HBsAg of IgM class in the blood from the first days of jaundice in the absence of HBsAg. All the 3 groups differed in the regularities of detection of humoral and cellular immunity and in clinical manifestations of the disease in the acute and convalescent periods. The most severe forms of the disease are associated with the early appearance of free anti-HBs in the blood and a significant decrease in the levels of T-lymphocytes which may be used as immunologic markers for prognosis of the disease.
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