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  • Title: [Effect of seduksen (diazepam) on cortical P300 potentials evoked by neutral and emotional words].
    Author: Kostandov EA, Arzumanov IuL, Zakharova NN.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1983; 33(3):449-55. PubMed ID: 6613337.
    Abstract:
    The influence of seduxen (diazepam) on cortical potentials P300 evoked by neutral and emotional words was studied in adult subjects having life conflicts. The therapeutic dose of seduxen (10 mg) had no significant effect on the amplitude of the late positive cortical response P300 to neutral words. Seduxen depresses the emotional activation of the cerebral cortex; that is manifested in selective elimination of those changes in latency and amplitude of P300 wave which are observed in response to emotionally significant words. Under the action of seduxen, the interhemispheric difference in the latency of cortical response disappears due to latency increase in the right hemisphere.
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