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  • Title: Gamma-vinyl-GABA: a single-blind trial in patients with epilepsy.
    Author: Gram L, Lyon BB, Dam M.
    Journal: Acta Neurol Scand; 1983 Jul; 68(1):34-9. PubMed ID: 6613525.
    Abstract:
    The anti-epileptic effect of gamma-vinyl-GABA (GVG) was studied using a placebo-controlled, single-blind design in 15 patients with therapy-resistant epilepsy, the majority experiencing complex partial seizures. GVG was added to concomitant treatment, which was kept at constant serum levels. Following administration of 1 g, 2 g and 3 g per day, significant reductions in seizure frequency were observed. A poor correlation was found between GVG serum levels and clinical effect. Only mild and transient side-effects were observed.
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