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  • Title: Inhibition of compound 48/80 induced mediator release following oral administration of tiaramide hydrochloride in normal subjects.
    Author: Sussman GL, Petillo JJ, Zisblatt M, Vukovich RA, Neiss ES, Schocket AL.
    Journal: Ann Allergy; 1983 Sep; 51(3):367-70. PubMed ID: 6614599.
    Abstract:
    The ability of tiaramide hydrochloride (RHC 2592) to inhibit cutaneous reactivity was studied using 11 normal volunteers. After repeated administration tiaramide hydrochloride inhibited cutaneous mast cell mediator release induced by compound 48/80 while not affecting histamine-induced cutaneous reactivity. This is the first demonstration in man of an oral agent with such an effect.
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