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  • Title: Hyperoxia damages cultured endothelial cells causing increased neutrophil adherence.
    Author: Bowman CM, Butler EN, Repine JE.
    Journal: Am Rev Respir Dis; 1983 Sep; 128(3):469-72. PubMed ID: 6614640.
    Abstract:
    Exposure of cultured bovine pulmonary artery endothelial cells to hyperoxia (95% O2) caused cellular injury manifested by decreased growth rates and release of cytoplasmic lactic dehydrogenase (LDH). In addition, a greater number of polymorphonuclear leukocytes (PMN) adhered to endothelial cells that had been exposed to hyperoxia for 24 or 48 h than to control endothelial cells that had been exposed to normoxia (15% O2). Direct endothelial cell injury from hyperoxia may contribute to vascular damage and the increased PMN accumulation seen in lungs of animals exposed to hyperoxia.
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