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  • Title: Schizophrenia subdivided by the family history of affective disorder. A comparison of symptomatology and course of illness.
    Author: Kendler KS, Hays P.
    Journal: Arch Gen Psychiatry; 1983 Sep; 40(9):951-5. PubMed ID: 6615157.
    Abstract:
    Schizophrenics meeting DSM-III criteria were divided, based on family history of affective disorder in first-degree relatives, into three groups: N-schizophrenics, no relative with affective disorder; U-schizophrenics, a relative with unipolar affective disorder; and B-schizophrenics, a relative with bipolar affective disorder. Although N- and U-schizophrenics displayed similar symptoms during the prodromal, actively psychotic, and remitted stages of their illness, U-schizophrenics were significantly more likely to have a depressive syndrome develop during the follow-up period. Compared with N-schizophrenics, B-schizophrenics were more depressed during the prodrome, were more elated and catatonic when actively psychotic, had fewer residual symptoms when remitted, and were much more likely to have a manic syndrome develop during the follow-up period. Even when DSM-III criteria are met, hesitation is indicated in diagnosing schizophrenia in patients with a first-degree relative with bipolar illness.
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