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  • Title: Compound action potential input-output decruitment. Effect of topically applied antiseptics.
    Author: Morizono T, Sikora MA.
    Journal: Arch Otolaryngol; 1983 Oct; 109(10):677-81. PubMed ID: 6615320.
    Abstract:
    The ototoxic effect of povidone-iodine antiseptics topically applied to the chinchilla round window was examined with particular emphasis on the action potential (AP) input-output function at 2 and 4 kHz. A group of chinchillas exhibited a marked elevation of AP threshold at 8 and 12 kHz, with only a slight threshold elevation at 2 and 4 kHz. A distinct decruitment (less than normal growth of response with increasing sound intensity) of the AP input-output function was, however, found at the lower frequencies. There are implications of an ototoxically induced high-frequency hearing loss on speech frequencies.
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