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  • Title: The 60S ribosomal subunit is altered in the skeletal muscle of dystrophic hamsters.
    Author: Jolicoeur C, Noël J, Brakier-Gingras L.
    Journal: Biochem Biophys Res Commun; 1983 Aug 30; 115(1):153-8. PubMed ID: 6615523.
    Abstract:
    Polysomes from the skeletal muscle of normal and dystrophic hamsters were dissociated into ribosomal subunits by treatment with puromycin and the subunits from both strains were reassociated in all possible combinations. When their protein synthesis activity was assayed in a poly(U)-directed cell-free system at a low magnesium concentration, the reassociated ribosomes from dystrophic hamsters were less active than the ribosomes from control animals. The ribosomal defect is a property of the 60S subunit and is due to a ribosomal component rather than to abnormal binding of a non-ribosomal protein.
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