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  • Title: Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis.
    Author: Dew MJ, Ryder RE, Evans N, Evans BK, Rhodes J.
    Journal: Br J Clin Pharmacol; 1983 Aug; 16(2):185-7. PubMed ID: 6615691.
    Abstract:
    5-amino salicylic acid coated with acrylic based resin was given orally to eight patients with active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in the terminal ileum and proximal colon. Differences between individuals were marked; the plasma 'concentration-time profile' reflected variations in the time taken for tablets to reach the terminal ileum.
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