These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Energy-dependent inhibition of mitochondrial NAD.H-oxidase and succinic oxidase by strong nitrous bases].
    Author: Galkina VG, Iaguzhinskiĭ LS.
    Journal: Nauchnye Doki Vyss Shkoly Biol Nauki; 1983; (7):17-21. PubMed ID: 6615929.
    Abstract:
    The inhibitory effect of organic cations from the group of hydrazones on phosphorylated respiration in mitochondria with a succinate as a substrate has been shown to be completely reversed by 2,4-dinitrophenol (DNP). The effect observed has not been due to the action directly on the ATP-synthetase because the inhibition of ATPase, NADH-succinate oxidase and ascorbate oxidase activities occurs at a wide concentration range of compounds studied. The concentration of organic cations used for the inhibition of the respiration in submitochondria particles (SMP) as compared with respiration in mitochondria is higher; in case of SMP the inhibitory effect is not reversed by DNP. These results allow to conclude that the high inhibitory effect of organic cations is due to the energy-dependent binding of these compounds to the enzyme in the membrane phase of mitochondria.
    [Abstract] [Full Text] [Related] [New Search]