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  • Title: Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor.
    Author: Roth KA, Evans CJ, Weber E, Barchas JD, Bostwick DG, Bensch KG.
    Journal: Cancer Res; 1983 Nov; 43(11):5411-5. PubMed ID: 6616473.
    Abstract:
    Recent immunohistochemical findings have indicated the presence of gastrin-releasing peptide in normal and pathological human lungs. Gastrin-releasing peptide is a 27-amino acid peptide isolated from porcine gut which bears considerable carboxyterminal homology with bombesin. We have characterized the gastrin-releasing peptide-like peptides present in a human malignant lung carcinoid tumor by gel chromatography and reverse-phase high-performance liquid chromatography. Our results show that this tumor did not contain bombesin; however, this tumor expressed a gastrin-releasing peptide-like compound, several amino-terminal fragments, and a carboxy-terminal fragment of gastrin-releasing peptide.
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