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  • Title: Chronobiological aspects of headache syndromes due to sellar or pituitary pathology.
    Author: Bossolo P, Canepari C, Daguati MM, Cozzi A, Fioravanti M, Ferrari E.
    Journal: Cephalalgia; 1983 Aug; 3 Suppl 1():117-21. PubMed ID: 6616594.
    Abstract:
    A chronobiological study was carried out in headache syndromes due to empty sella or to pituitary G.H.- and PRL-secreting adenomas. In the empty sella syndrome only the chrono-organization of G.H. secretion was disturbed, whereas pl. PRL exhibited the usual circadian pattern. The circadian rhythms of pl. G.H. and pl. PRL were abolished in G.H.- and PRL-secreting pituitary tumors, respectively, and were again detectable when patients were cured by selective transsphenoidal adenomectomy. A normal circadian rhythmicity of pl. cortisol was demonstrable in the empty sella syndrome and in pituitary adenomas, both before and after surgery.
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