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  • Title: Production of a monoclonal antibody to autoantigenic components of human glomerular basement membrane.
    Author: Pressey A, Pusey CD, Dash A, Peters DK, Lockwood CM.
    Journal: Clin Exp Immunol; 1983 Oct; 54(1):178-84. PubMed ID: 6616967.
    Abstract:
    We describe a mouse monoclonal antibody which reacts on immunoblotting with those components of collagenase digested human glomerular basement membrane (GBM) that are also recognized by autoantibodies in sera from patients with anti-GBM nephritis. Competition between the monoclonal antibody and anti-GBM autoantibodies was demonstrated in a solid phase radioimmunoassay, suggesting that both are directed against the same autoantigen.
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