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  • Title: Effects of synthetic steroid contraceptives on biliary lipid composition of normal Mexican women.
    Author: Etchegoyen G, Wolpert E, Galván E, Landeros J, Pérez-Palacios G.
    Journal: Contraception; 1983 Jun; 27(6):591-603. PubMed ID: 6617205.
    Abstract:
    The effects of two hormonal contraceptives upon the biliary lipid composition of Mexican women were evaluated in a prospective study. Twenty-one healthy volunteers of reproductive age were allocated into three groups (7 subjects each). Group I served as the experimental control (all subjects were bearing a non-medicated IUD), group II received i.m. norethisterone enanthate (NET-e) 200 mg every two months, and group III received an oral combination of 1-norgestrel 150 micrograms and ethinyl estradiol 30 micrograms. The bile lithogenic index as assessed by the relative proportion of cholesterol to bile acids and lecithin was determined in duodenal bile samples obtained before (baseline), during (4 months), and after (12 months) contraceptive administration. The results indicated that NET-e administration resulted in a slight although significant increase of the lithogenic index while the oral formulation did not. The overall data were interpreted as demonstrating that administration of these steroid contraceptives does not constitute a risk factor in terms of gallstone formation in the population studied. The estrogen-like behavior exhibited by NET-e is discussed. The effects of 2 hormonal contraceptives upon the biliary lipid composition of Mexican women were evaluated in a prospective study. 21 healthy volunteers of reproductive age were assigned to 3 groups (7 subjects each). Group 1 served as the experimental control (all subjects wore a nonmedicated IUD), group 2 received 200 mg norethisterone enanthate (NET-e) intramuscularly every 2 months, and group 3 received an oral combination of 150 mcg l-norgestrel and 30 mcg ethinyl estradiol. The bile lithogenic index as assessed by the relative proportion of cholesterol to bile acids and lecithin was determined in duodenal bile samples obtained before (baseline), during (4 months), and after (12 months) contraceptive administration. Results indicated that NET-e administration resulted in a slight although significant increase of the lithogenic index while the oral formulation did not. The overall data were interpreted as demonstrating that administration of these steroid contraceptives does not constitute a risk factor in terms of gallstone formation in the population studied. The estrogen-like behavior exhibited by NET-e is discussed.
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