These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Continuous infusion of high-dose metoclopramide for the prevention of nausea and vomiting in patients receiving cancer chemotherapy.
    Author: Joss RA, Galeazzi RL, Brunner KW.
    Journal: Eur J Clin Pharmacol; 1983; 25(1):35-9. PubMed ID: 6617723.
    Abstract:
    Fourteen patients undergoing strongly emetic cancer chemotherapy received a total of 33 continuous infusions of high-dose metoclopramide to prevent nausea and vomiting. Metoclopramide 2 mg/kg was given as an i.v. infusion over 15 min followed by continuous infusion over 13 h of 5 mg/kg. The antiemetic response could be evaluated in 12 patients receiving their first continuous metoclopramide infusion. Six patients were partly or completely protected from acute gastrointestinal disturbances. Three patients experienced a short-lived extrapyramidal syndrome during the continuous metoclopramide infusions. Other side effects observed were mild. Thus, high-dose metoclopramide given as a continuous infusion is an effective antiemetic treatment in patients receiving cancer chemotherapy.
    [Abstract] [Full Text] [Related] [New Search]