These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Apparent down-regulation of muscarinic acetylcholine receptors of neuroblastoma cells by pilocarpine is due to occluded agonist.
    Author: Milligan G, Strange PG.
    Journal: Eur J Pharmacol; 1983 Jul 22; 91(2-3):223-8. PubMed ID: 6617743.
    Abstract:
    Down-regulation of muscarinic acetylcholine receptors on N1E 115 neuroblastoma cells caused by muscarinic agonists has been studied. Whereas the potent agonist carbachol provokes a true down-regulation of receptors, the down-regulation caused by the partial agonist pilocarpine is only apparent and is actually due to the presence of pilocarpine taken up by the cells and released into the binding assays upon cell breakage.
    [Abstract] [Full Text] [Related] [New Search]