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  • Title: [Antiheparin and toxic properties of quaternary ammonium salts of the monodispersed oligomers of conidine].
    Author: Efimov VS, Chernova OV, Berestetskaia TZ, Nekrasov AV.
    Journal: Farmakol Toksikol; 1983; 46(4):57-61. PubMed ID: 6617837.
    Abstract:
    A distinct relationship has been demonstrated of antiheparin and toxic properties of quaternary ammonium salts of monodispersed oligomers of conidine to their molecular weight and, therefore, to the length of the macromolecular chain. Conidine monomer having the highest acute toxicity does not interact with heparin. As the number of functional links is increased up to 25, antiheparin activity of the compounds under study ascends, whereas toxic effects become less powerful. An oligomer with 25 functional links has appeared to be the best combination of the characteristics under consideration. Further increase of the chain length and, therefore, of the molecular weight is followed by a slight lowering of anticoagulant activity and increase of acute toxicity.
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