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  • Title: Synthesis and antimicrobial activity of monoalkylcarbamic and thiocarbamic esters of 3-mercapto-1,2,4-benzothiadiazine-1,1-dioxide and of its Bz-derivatives.
    Author: Di Bella M, Gamberini G, Tait A, Fabio U, Quaglio GP.
    Journal: Farmaco Sci; 1983 Jul; 38(7):466-72. PubMed ID: 6617846.
    Abstract:
    A new series of monoalkylcarbamic esters of 3-mercapto-1,2,4-benzothiadiazine-1,1-dioxide (I) and of its 6-chloro- and 5,7-dichloroderivatives [compounds (II leads to XVI)] and a series of monoalkylthiocarbamic esters of (I) [compounds (XVII leads to XIX)] were synthesized and evaluated in vitro for antimicrobial activity. All the substances studied have been found to possess an inhibiting action on one or more strains of mycetes of the genus Candida and on some strains of Gram-positive bacteria belonging to the genus Staphylococcus. Moreover, some compounds have shown a bacteriostatic effect on a strain belonging to the genus Streptococcus. None of the substances tested was active on Gram-negative schizomycetes.
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