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  • Title: Comparative binding studies of anticonvulsant drugs to bovine serum albumin.
    Author: Dal Pozzo A, Acquasaliente M, Tajana A.
    Journal: Farmaco Sci; 1983 Aug; 38(8):609-18. PubMed ID: 6617856.
    Abstract:
    The ability of a new anticonvulsant drug, denzimol, to interact with bovine serum proteins has been studied, in comparison with diphenylhydantoin and carbamazepine. Albumin proved to be the protein fraction responsible for the binding. The association constants were determined in vitro by means of equilibrium dialysis. Additional investigations showed that there was no consistent inhibition by denzimol of the other two drugs binding and vice versa. These data were obtained as a preliminary evaluation of the influence of protein binding in vivo.
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