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  • Title: Effect of S-100 protein on microtubule assembly-disassembly.
    Author: Endo T, Hidaka H.
    Journal: FEBS Lett; 1983 Sep 19; 161(2):235-8. PubMed ID: 6617876.
    Abstract:
    S-100 protein was examined for its ability to affect microtubule assembly-disassembly in vitro. Addition of S-100 protein inhibited microtubule assembly in a dose-dependent manner in the presence of Ca2+, but this effect was not observed in the presence of 2 mM EGTA. The interaction of microtubule proteins with S-100 protein was also demonstrated by Ca+-dependent affinity chromatography on S-100 protein-Sepharose. The proteins bound to the Sepharose column comigrated with tubulin as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These results might suggest a possible physiological role of S-100 protein in the microtubule assembly-disassembly system.
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