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  • Title: [Oriented complexes of nucleic acids with low-molecular weight ligands. I. Anisotropy of the absorbance of DNA complexes with distamycin A and its analogs].
    Author: Sveshnikov PG, Grokhovskii SL, Zhuze AL, Kondrat'eva NO, Makarov VL.
    Journal: Mol Biol (Mosk); 1978; 12(3):557-64. PubMed ID: 661823.
    Abstract:
    The anisotropy of absorbance (near 320 and 258 nm) of the DNA complexes with distamycin A and two analogues have been studied. Measurements were made along the direction of the flow oreintation of the complexes. The comparison of two orientation effects: deltaA320=(Astop--Aflow)320 and deltaA258=(Astop--Aflow)258, gave the opportunity to estimate the inclination angle of distamycin chromophores with respect to the DNA axis: for all three analogues the angle was lying between 40 and 45 degrees. These results strongly support the model of the complex where the antibiotic is inserted into the narrow grove of the DNA helix.
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