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  • Title: Influence of thrombin inhibitors on the thrombin-induced activation of human blood platelets.
    Author: Markwardt F, Hoffmann A, Stürzebecher J.
    Journal: Haemostasis; 1983; 13(4):227-33. PubMed ID: 6618289.
    Abstract:
    The influence of thrombin inhibitors, which differ both in their chemical structure and type of inhibition, on the thrombin-platelet reaction was studied. The inhibitory effects of the competitive inhibitors tested on the thrombin-induced platelet reaction correlated well with their effects on the thrombin-catalyzed fibrinogen conversion and on the thrombin-catalyzed hydrolysis of synthetic substrates. Heparin and antithrombin III inhibited the thrombin-induced platelet reaction. However, heparin did not potentiate the inhibition by antithrombin III of the thrombin-platelet reaction.
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