These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Analysis of spontaneous, carcinogen-induced and promoter-induced chromosomal instability in patients with hereditary retinoblastoma.
    Author: Gainer HS, Kinsella AR.
    Journal: Int J Cancer; 1983 Oct 15; 32(4):449-53. PubMed ID: 6618708.
    Abstract:
    Skin fibroblasts from patients with hereditary retinoblastoma (RB cells) were examined since predisposition to the tumour might be expected to involve some degree of chromosomal instability, as has been noted for several cancer-prone conditions. Spontaneous and N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced aberration frequencies were measured, the cytogenetic effects of long-term treatment with 12-O-tetradecanoyl-phorbol-13acetate (TPA) were examined and also the spontaneous and TPA-induced sister chromatid exchange (SCE) frequencies. In all the studies the RB cells behaved in a similar fashion to normal human skin fibroblasts.
    [Abstract] [Full Text] [Related] [New Search]