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  • Title: [Fundamental and clinical studies of T-1982 (cefbuperazone) in the field of obstetrics and gynecology].
    Author: Hiraike H, Takashima H, Haruta T, Kobayashi Y.
    Journal: Jpn J Antibiot; 1983 May; 36(5):1054-60. PubMed ID: 6620556.
    Abstract:
    Human pharmacokinetics and clinical studies of T-1982 (cefbuperazone) were carried out and the following results were obtained. Transference into pelvic cavity fluid T-1982 level in pelvic cavity fluid showed the peak level of 48.0 micrograms/ml at 30 minutes after 2 hours drip infusion of 1 g in 1 case. The concentration tended to be more sustained than that of venous blood. Clinical study T-1982 was administered to 2 cases with pelveoperitonitis, 2 cases with puerperal fever and 1 case with adnexitis at a dose of 1 g twice a day for a period of 4 or 5 days. The clinical effect was excellent in 3 and good in 2 cases. Neither side effects nor abnormalities of laboratory findings were observed.
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