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  • Title: [Therapeutic effect of the beta-adrenergic receptor blocker corgard (nadolol) and its effect on hemodynamics in hypertensive patients].
    Author: Charyev KhE, Erina EV.
    Journal: Kardiologiia; 1983 Aug; 23(8):17-21. PubMed ID: 6620829.
    Abstract:
    The therapeutic effect of the non-cardioselective beta-blocker corgard (nadolol) was examined in 40 patients with stage II essential hypertension. In 22 of those, central, intracardiac and regional hemodynamics were measured echocardiographically and rheographically after 2 and 4 weeks of treatment. Blood pressure dropped significantly by days 8-13 of treatment, as a result of cardiac index reduction mainly due to decreased heart rate. At the same time, a moderate yet significant rise in total peripheral vascular resistance was noted. Intramyocardial tension decreased, as did the thickness of the left-ventricular posterior wall and interventricular septum, which caused a significant (6.74%) reduction in myocardial weight.
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