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  • Title: Adenine nucleotide and phosphoenolpyruvate transport by bovine chromaffin granule "ghosts".
    Author: Grüninger HA, Apps DK, Phillips JH.
    Journal: Neuroscience; 1983 Aug; 9(4):917-24. PubMed ID: 6621884.
    Abstract:
    Purified bovine adrenal chromaffin granule "ghosts" (resealed membranes) accumulate nucleotides and phosphoenolpyruvate in a temperature-dependent process. Equilibration takes several hours, the compounds being accumulated to not more than twice their concentration in the medium. This uptake occurs primarily by a non-saturable diffusion process, and rates and extents show little dependence on membrane energization. Uptake rates are inhibited less than 50% by compounds that discharge the "ghost" membrane potential, or by atractylate or low concentrations of Cibacron Blue. The data gave little support to the theory that chromaffin granules have a membrane potential-dependent adenine nucleotide transport process and that nucleotides are in equilibrium with the positive-inside potential across the granule membrane.
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