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  • Title: Screening for impurities in butoprozine.
    Author: Drenth BF, Jagersma T, Wormeester AJ, de Zeeuw RA.
    Journal: Pharm Weekbl Sci; 1983 Aug 26; 5(4):149-52. PubMed ID: 6622208.
    Abstract:
    The purity analysis of butoprozine is described. Both gas chromatography-mass spectrometry (GC-MS) and high pressure liquid chromatography (HPLC) with UV-vis detection (conventional and multichannel) were used. In the butoprozine example disadvantages for both techniques became apparent: incorrect conclusions with regard to the purity of the drug would have been drawn if only one of these chromatographic techniques had been used. GC-MS allowed the identification of an impurity not found by HPLC.
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