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  • Title: In vitro neurotoxic esterase assay using leptophos oxon analogs as inhibitors.
    Author: Reinders JH, Hansen LG, Metcalf RL.
    Journal: Toxicol Lett; 1983 Jun; 17(1-2):107-11. PubMed ID: 6623496.
    Abstract:
    In comparing neurotoxic esterase (NTE) inhibition properties of a series of phenylphosphonates, it was discovered that certain compounds including leptophos inhibited mipafox-insensitive phenylvalerate hydrolases. This leads to erroneous values for NTE inhibition which can be corrected by a differential assay: the total amount of mipafox-insensitive activity is determined with O-(2,6-dichlorophenyl)O-methyl phenylphosphonate and subtracted from the apparent NTE determined with the test compound before calculating pI50's.
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