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  • Title: Phenylbutazone-induced nephrotoxicity in the rat.
    Author: Owen RA, Heywood R.
    Journal: Toxicol Lett; 1983 Jun; 17(1-2):117-24. PubMed ID: 6623497.
    Abstract:
    Male Wistar rats showed reduced urinary concentrating ability after 2 weeks' administration of phenylbutazone at 200 mg/kg/day. Male Sprague-Dawley rats showed progressive proteinuria and developed renal papillary necrosis when given phenylbutazone at 200 mg/kg/day for 13 weeks. It is suggested that strain differences exist in the nephrotoxic profiles of rats given high doses of phenylbutazone.
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