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  • Title: Genotoxicity of chlordiazepoxide hydrochloride on the bone-marrow cells of Swiss mice.
    Author: Susheela M, Rao MS.
    Journal: Toxicol Lett; 1983 Aug; 18(1-2):45-8. PubMed ID: 6623547.
    Abstract:
    The mutagenic effect of chlordiazepoxide hydrochloride was evaluated in the bone-marrow cells of Swiss mice by the micronucleus test. A comparative study of the drug was made by oral and intraperitoneal administrations containing 187.5, 375 and 562 mg/kg body weight and 67, 134 and 201 mg/kg body weight respectively, corresponding to three sublethal doses of 1/4, 1/2, and 3/4 LD50, respectively. Bone-marrow preparations were made and slides scored for the presence of micronuclei in the developing erythrocytes. The results showed that the drug chlordiazepoxide induced a significant increase of micronuclei in the polychromatic erythrocytes by both routes of administration.
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