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  • Title: [Effect of somatotropin on the activity of mitochondrial alpha-glycerophosphate dehydrogenase in the liver of rats with hypo- and hyperthyroidism].
    Author: Martynenko FP, Korniushenko NP.
    Journal: Ukr Biokhim Zh (1978); 1983; 55(4):449-52. PubMed ID: 6623672.
    Abstract:
    The activity of mitochondrial alpha-glycerophosphate dehydrogenase in the liver of rats with hypothyrosis (two weeks after total thyroidectomy) is 36% of the normal level; in rats with hyperthyrosis (three weeks after subcutaneous implantation 2 mg of l-thyroxin on a kaolin base) it is 7.4 times as high. Bovine somatotropin (0.5 mg per 100 g of body mass) injected subcutaneously for 10 days has no effect on the enzyme activity in intact rats and in rats with hypothyrosis. In animals with hyperthyrosis somatotropin produces a 37% decrease in the enhance activity of the enzyme. Somatotropin fully normalizes a 25% increased amount of protein in the liver mitochondrial fractions of rats with hyperthyrosis.
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