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  • Title: [Mechanisms of pathologic and recuperative processes in brain tissue cells in the postischemic period according to an electron-cytochemical analysis of nuclear chromatin and ribonucleoproteins].
    Author: Semchenko VV, Stepanov SS.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1983; 83(7):980-4. PubMed ID: 6624330.
    Abstract:
    A pattern of changes in chromatin and ribonucleoprotein (RNP) particles occurring in different cells of the cerebral cortex in rats during the first 30 days of the postischemic period was studied by an electron cytochemical method. It was shown that the pathological conditions of cells were occasioned by changes in the nuclear synthesis of RNA and by disruption of its nucleocytoplasmic transport. Characteristic features of the time course of changes in nuclear chromatin on the one hand and of the relationship between various RNP particles in hypo- and hyperchromic neurons, glial cells and blood carrying capillaries on the other explain some of the mechanisms of their heterogeneous sensitivity to hypoxia. The recovery, first, of RNA synthesis and, secondly, of its transport into the cytoplasm represents the first stage of reparative changes.
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