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  • Title: Idiotypic/antiidiotypic interactions in systemic lupus erythematosus: demonstration of oscillating levels of anti-DNA autoantibodies and reciprocal antiidiotypic activity in a single patient.
    Author: Zouali M, Eyquem A.
    Journal: Ann Immunol (Paris); 1983; 134C(3):377-91. PubMed ID: 6625532.
    Abstract:
    This work was designed to investigate the occurrence and evolution of autoantiidiotypic antibodies to double-stranded DNA in systemic lupus erythematosus (SLE). Serum samples from a patient with SLE who was submitted to repeated therapeutic plasmapheresis for 57 weeks were examined for the presence of autoantiidiotypic antibodies to DNA. Anti-DNA antibodies were affinity-purified from a serum sample obtained at the beginning of the observation period. Anti-anti-DNA activity, directed toward structures within the binding site of anti-DNA autoantibodies but not antibodies of another specificity, was detected in the serum of the patient. In addition, the decrease in the levels of anti-DNA antibodies took place concomitantly with a reciprocal increase in the autologous anti-idiotype. These results indicate that anti-DNA and anti-anti-DNA antibodies coexist in the serum of this patient, and suggest that antiidiotypic interactions may play a role in the modulation of idiotypic expression in SLE.
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