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  • Title: Factor V deficiency and its reversal with gluten restriction. In a patient with celiac disease.
    Author: Shanahan F, Aburajab A, Goodacre R, Blajchman MA.
    Journal: Arch Intern Med; 1983 Oct; 143(10):2009-10. PubMed ID: 6625791.
    Abstract:
    Hemorrhagic manifestations in patients with celiac disease are uncommon and, when present, are usually due to a deficiency of the vitamin K-dependent clotting factors. A patient with celiac disease was seen with a severe bleeding diathesis associated with deficiencies of factor V. The deficiencies of vitamin K-dependent clotting factors were rapidly reversed with parenteral administration of phytonadione. Factor V levels returned to normal levels only after gluten restriction.
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